Special Warnings and Precautions for Use

Concomitant use of alcohol/CNS depressants.

Patients should be advised that their tolerance for alcohol and other CNS depressants (including anxiolytics, sedatives, antidepressants including tricyclic anti-depressants and non-selective MAO inhibitors, sedative antihistamines, opioids and anaesthetics) will be diminished and that these medications should either be eliminated or given in reduced dosage in the presence of Valium. Such concomitant use has the potential to increase the clinical effects of Valium, possibly including severe sedation that could result in coma or death, clinically relevant respiratory and/or cardiovascular depression (see Section 4.5 Interactions with Other Medicines and Other Forms of Interactions). Buy Valium Roche diazepam 5mg for sale online Australia

Tolerance.

In general, benzodiazepines should be prescribed for short periods only (e.g. 2-4 weeks). Continuous long-term use of Valium is not recommended. There is evidence that tolerance develops to the sedative effects of benzodiazepines. After as little as one week of therapy, withdrawal symptoms can appear following the cessation of recommended doses (e.g. rebound insomnia following cessation of a hypnotic benzodiazepine).
Tolerance, as defined by a need to increase the dose in order to achieve the same therapeutic effect, seldom occurs in patients receiving recommended doses under medical supervision. Tolerance to sedation may occur with benzodiazepines, especially in those with drug seeking behaviour. Buy Valium Roche diazepam 5mg for sale online Australia

Drug abuse and dependence.

Dependence.

Use of benzodiazepines and benzodiazepine-like agents may lead to the development of physical and psychological dependence (see Section 4.8 Undesirable Effects (Adverse Effects)), as defined by the presence of a withdrawal syndrome on discontinuation of the drug. The risk of dependence increases with dose and duration of treatment. It is more pronounced in patients on long-term therapy and/or high dosage and particularly so in predisposed patients with a history of alcohol or drug abuse. Abuse has been reported in poly-drug abusers. Valium should be used with extreme caution in patients with a history of alcohol or drug abuse. Buy Valium Roche diazepam 5mg for sale online Australia

Withdrawal.

When benzodiazepines are used, withdrawal symptoms may develop when switching to a benzodiazepine with a considerably shorter half-life.
Withdrawal symptoms, similar in character to those noted with barbiturates and alcohol, have occurred once physical dependence to benzodiazepines has developed or following abrupt discontinuation of benzodiazepines. They may consist of headache, diarrhoea, muscle pain, insomnia, extreme anxiety, tension, restlessness, confusion and irritability. In severe cases, the following symptoms may occur: dysphoria, palpitations, panic attacks, vertigo, myoclonus, akinesia, hypersensitivity to light. Buy Valium Roche diazepam 5mg for sale online Australia

Rebound anxiety.

A transient syndrome whereby the symptoms that led to treatment with Valium recur in an enhanced form. This may occur on withdrawal of treatment. It may be accompanied by other reactions including mood changes, anxiety, sleep disturbances and restlessness.